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采用直流串单方波电刺激鼠尾部引起鼠嘶叫的电流值为动物痛阈指标，观察褪黑素（ Ｍ Ｔ） 对大鼠和小鼠的镇痛作用；进而观察纳络酮的拮抗作用，以探讨 Ｍ Ｔ 的镇痛作用与内源性阿片肽系统的关系。结果表明，ｉｐ Ｍ Ｔ 显著提高大鼠痛阈，具有明显的量效和时效关系；ｉｐ Ｍ Ｔ 也显著提高小鼠痛阈。表明 Ｍ Ｔ 对大鼠和小鼠均可产生显著的镇痛作用。纳洛酮显著拮抗 Ｍ Ｔ 对大鼠、小鼠的镇痛作用，提示 Ｍ Ｔ 的镇痛作用与内源性阿片肽系统有关。
The electric current value of mouse tail which caused by single-wave DC stimulation was used as animal pain threshold to observe the analgesic effect of melatonin (MT) on rats and mice. Then the antagonism of naloxone was observed, To investigate the analgesic effect of M T and endogenous opioid peptide system. The results showed that ip M T significantly increased pain threshold in rats, with significant dose-effect and time-dependent relationship; ip M T also significantly increased the pain threshold in mice. M T showed that rats and mice can produce significant analgesic effect. Naloxone significantly antagonized the analgesic effect of M T on rats and mice, suggesting that the analgesic effect of M T is related to the endogenous opioid peptide system.