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应用ＡＢ－ＰＡＰ免疫组化法，研究了６６例大肠癌ｐ５３蛋白的表达及其与细胞增殖活性、淋巴结转移及生存期的关系。结果显示：６２．１％大肠癌组织中存在ｐ５３蛋白的异常表达。ｐ５３蛋白阳性的大肠癌其细胞增殖活性及淋巴结转移机率均较阴性者高（Ｐ＜０．０５）。其生存期也较阴性者明显缩短（Ｐ＜０．０５）。结果提示：ｐ５３基因的突变以及由此导致的细胞异常增殖不仅与大肠癌的发生有关，而且在其淋巴结转移中也起重要作用。检测ｐ５３蛋白表达对判断肿瘤的恶性程度及预测预后有重要参考价值。
AB-PAP immunohistochemical method was used to study the expression of p53 protein in 66 cases of colorectal cancer and its relationship with cell proliferation activity, lymph node metastasis and survival time. The results showed that 62.1% of colorectal cancer tissues had abnormal expression of p53 protein. In the colorectal cancer with positive p53 protein, the cell proliferation activity and lymph node metastasis were higher than those in the negative (P<0.05). The survival time was also significantly shorter than that of the negative (P<0.05). The results suggest that the mutation of p53 gene and the resulting abnormal cell proliferation are not only related to the occurrence of colorectal cancer, but also play an important role in the lymph node metastasis. Detecting the expression of p53 protein has important reference value for judging the malignant degree of tumor and predicting the prognosis.