论文部分内容阅读
Praziquantel是一种新型高效的广谱抗血吸虫化合物。它对感染曼氏血吸虫的小鼠、多乳鼠和仓鼠,无论是口服给药或注射都有良好疗效。减虫率达到95%以上所需的总剂量因宿主的种类、给药途径和疗法而异。小鼠的总剂量一般为200～1,000毫克/公斤,多乳鼠和仓鼠为500毫克/公斤。总剂量分为3剂或更多剂在1天内给药比之总剂量一次口服的疗效要高近1倍。单剂皮下注射的疗效比单剂口服略优,单剂肌肉注射比单剂口服疗效高1倍。本药对刚侵入皮肤的血吸虫极为有效,对7天内的童虫效果较差,对2～4周的童虫效果更差,但对5周或5周以上的血吸虫又有效。此药对曼氏血吸虫的雌虫和雄虫有同样效果,对未合抱的幼年雌虫效果较差,但对未合抱的雄虫完全有效。小鼠的
Praziquantel is a new and highly effective broad-spectrum anti-schistosome compound. It has a good effect on mice infected with Schistosoma mansoni, neonatal rats and hamsters, whether orally administered or injected. The total dose required to achieve a worm reduction rate of 95% or more will vary depending on the host species, route of administration and therapy. The total dose of the mice is generally 200 to 1,000 mg / kg, and that of the polygamy and hamster is 500 mg / kg. A total dose of 3 or more doses administered in 1 day is nearly twice as effective as an oral dose of the total dose. The efficacy of single-dose subcutaneous injection is slightly better than that of single-dose oral administration, and single-dose intramuscular injection is twice as effective as single-dose oral administration. The drug is very effective on the fresh schistosomiasis that invaded the skin. It is less effective against schistosomiasis within 7 days, less effective against 2 to 4 weeks of schistosomiasis, and more effective against schistosomiasis for more than 5 weeks. This medicine has the same effect on females and males of Schistosoma mansoni but is less effective on juvenile females that do not hold but is completely effective against unacceptable males. Mouse