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目的研究P27KIP1、P53、P21WAF1/CIP1蛋白表达与胃癌临床病理及预后的关系。方法应用免疫组织化学SP法检测90例胃癌组织中P27KIP1、P53、P21WAF1/CIP1的表达。结果90例胃癌组织中P27KIP1、P53、P21WAF1/CIP1阳性表达率分别为48.9%、56.7%、51.1%;随肿瘤分化程度降低、浸润深度加深、恶性程度增加,P27KIP1、P21WAF1/CIP1阳性表达率逐渐降低(P<0.05),P53阳性表达则相反;P27KIP1与P53、P21WAF1/CIP1表达显著相关(P<0.05);P27KIP1、P21WAF1/CIP1表达与胃癌预后密切相关(P<0.05),P53表达与患者术后生存无显著相关(P>0.05)。结论P27KIP1、P53、P21WAF1/CIP1异常表达可加速细胞周期转化,促进胃癌的发生,其蛋白检测尤其是P27KIP1、P21WAF1/CIP1蛋白检测可作为判断胃癌恶性程度、预测肿瘤转移和预后的重要参考指标。
Objective To study the relationship between P27KIP1, P53, P21WAF1 / CIP1 protein expression and the clinicopathologic features and prognosis of gastric cancer. Methods The expressions of P27KIP1, P53, P21WAF1 / CIP1 in 90 cases of gastric carcinoma were detected by immunohistochemical SP method. Results The positive rates of P27KIP1, P53 and P21WAF1 / CIP1 in gastric cancer tissues were 48.9%, 56.7% and 51.1% respectively. The positive expression rates of P27KIP1 and P21WAF1 / CIP1 gradually decreased with the differentiation degree of tumor decreased, the depth of invasion and malignancy increased (P <0.05). The expression of P27KIP1 was significantly correlated with the expression of P53 and P21WAF1 / CIP1 (P <0.05). The expressions of P27KIP1 and P21WAF1 / CIP1 were closely related to the prognosis of gastric cancer (P <0.05) There was no significant correlation between postoperative survival (P> 0.05). Conclusion The abnormal expression of P27KIP1, P53 and P21WAF1 / CIP1 can accelerate cell cycle transformation and promote the development of gastric cancer. The detection of protein, especially P27KIP1 and P21WAF1 / CIP1 protein, can be used as an important reference index to judge the malignant degree of gastric cancer and predict the metastasis and prognosis of gastric cancer.