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目的:探讨米非司酮联合米索前列醇用于稽留流产治疗的临床效果。方法:选取稽留流产患者120例,随机分为2组。对照组予乙烯雌酚口服,观察组予米非司酮口服联合米索前列醇阴道放置,在排出妊娠物排除之后或阴道出血量>100ml时及时进行清宫。结果:观察组患者妊娠物自然排除率明显高于对照组,手术时间、术中出血量、人工流产综合征以及再次清宫率、不良反应发生率均明显低于对照组,2组比较差异明显,有统计学意义(P<0.05)。2组患者术后阴道出血时间差别无统计学意义(P>0.05)。结论:对稽留流产患者实施米非司酮联合米索前列醇联合治疗,两种药物相辅相成,有效改善提高治疗成功率的同时,减少了患者的不良反应和并发症,减轻了患者的痛苦,且给药方便,是一种良好的治疗方法。
Objective: To investigate the clinical effect of mifepristone combined with misoprostol in the treatment of missed abortion. Methods: 120 cases of missed abortion were selected and randomly divided into 2 groups. The control group was given diethylstilbestrol orally, the observation group was given mifepristone oral combined with misoprostol vaginal discharge, after the exclusion of pregnant women or vaginal bleeding> 100ml timely clearance. Results: The spontaneous elimination rate of pregnancy in observation group was significantly higher than that in control group. The operation time, intraoperative blood loss, induced abortion syndrome, rate of recidivism and incidence of adverse reactions in observation group were significantly lower than those in control group. There was statistical significance (P <0.05). There was no significant difference in postoperative vaginal bleeding time between the two groups (P> 0.05). Conclusion: The combination of mifepristone and misoprostol in patients with missed abortion, the two drugs complement each other, effectively improve the success rate of treatment, while reducing the adverse reactions and complications of patients, reducing the suffering of patients, and Convenient delivery, is a good treatment.