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目的:探讨胰岛素样生长因子Ⅰ（IGF-Ⅰ）在恶性肿瘤组织中的表达及其意义。方法:采用免疫组化法检测肝癌、大肠癌、鼻咽癌、乳腺癌和肺癌共160例患者及50名正常人相应组织中IGF-Ⅰ的表达情况。结果：IGF-Ⅰ在上述恶性肿瘤组织中的表达率分别为81.1%，46.9%，38.7%，23.3%和20.0%；在正常组织中的表达率分别为50.0%，0%，10.0%，40.0%和300%。肝癌组织中IGF-Ⅰ的表达明显高于其他恶性肿瘤和正常组织，并与血清AFP有一定关系。结论：IGF-Ⅰ在恶性肿瘤尤其是肝癌的发生演变过程中有重要作用。
Objective: To investigate the expression and significance of insulin-like growth factor I (IGF-I) in malignant tumors. Methods: Immunohistochemistry was used to detect the expression of IGF-I in 160 cases of liver cancer, colorectal cancer, nasopharyngeal carcinoma, breast cancer and lung cancer. RESULTS: The expression rates of IGF-I in the above malignant tumors were 81.1%, 46.9%, 38.7%, 23.3% and 20.0%, respectively. The expression rates in normal tissues were 50.0%, 0%, 10.0%, 40.0, respectively. % and 300%. The expression of IGF-I in HCC tissue was significantly higher than other malignant tumors and normal tissues, and it had a certain relationship with serum AFP. Conclusion: IGF-I plays an important role in the development of malignant tumors, especially liver cancer.