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动脉粥样硬化及心肌梗塞与脂、脂蛋白代谢障碍有关。近10年,口服避孕药(OC_s)含乙炔雌二醇(EE)和各种19-去甲睾酮衍生的孕激素与脂代谢的关系引起重视和争论。炔诺酮和18-甲基炔诺酮或左旋18-甲基炔诺酮(LNG)已单独或与EE联合广泛用于避孕。这些孕激素制剂都有产生雄性征和抗雌激素性质,且大剂量时出现高密度脂蛋白-胆固醇(HDL-C)浓度下降或低密度脂蛋白-胆固醇(LDL-C)增加的副作用。如果适当减少孕激素成分和调整OC_s中雌激素与孕激素比值,可改善其性质。另外一些新类固醇药物对代谢的副反应轻微。Desogestrel(DOG)系LNG的3-deoxo-11-亚甲基衍生物对代谢的副反应与
Atherosclerosis and myocardial infarction and lipid, lipoprotein metabolism disorders. Over the past 10 years, oral contraceptives (OC_s) containing ethinyl estradiol (EE) and various 19-nortestosterone-derived progesterone and lipid metabolism caused by the attention and controversy. Norethisterone and 18-norgestrel or levonorgestrel (LNG) have been widely used in contraception, alone or in combination with EE. Both of these progestin formulations produce both male and anti-estrogenic properties with the side effects of either a decrease in high density lipoprotein-cholesterol (HDL-C) or an increase in low density lipoprotein-cholesterol (LDL-C) at high doses. If properly reduced progesterone composition and adjust OC_s estrogen and progesterone ratio, can improve its properties. Other new steroids have minor side effects on metabolism. Desogestrel (DOG) Department of LNG 3-deoxo-11-methylene derivative of the side effects of metabolism and