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目的 :观察洛赛克预防脑出血并发应激性溃疡出血的疗效。方法 :随机将 62例脑出血昏迷病人分为静脉应用洛赛克、西米替丁及胃管注入洛赛克片剂 (胶囊 ) 3组。全部病人置入胃管抽取胃液测量用药前后持续 7天的 p H值及潜血反应。结果 :胃液 p H值由用洛赛克前 1.3 7± 0 .70经用药后升至 5 .0 6± 0 .78(P<0 .0 1)。洛赛克静脉注入与胃管注入两组比较无差异 (P>0 .0 5 ) ,洛赛克两组与西米替丁组比较差异显著 (P<0 .0 1)。洛赛克静脉注入与胃内注入预防脑出血应激性溃疡出血疗效一致 ,总有效率均为 90 .4 8% ;应用西米替丁组有效率则为 65 % ,两组比较 P<0 .0 5。结论 :洛赛克能有效地预防脑出血并发应激性溃疡出血。
Objective: To observe the curative effect of Losec on the prevention of hemorrhagic stress ulcer caused by cerebral hemorrhage. Methods: 62 patients with cerebral hemorrhage coma were randomly divided into three groups: intravenous injection of Losec, cimetidine and gastric injection of Losec tablets. All patients were placed in gastric tube gastric juice extraction before and after treatment for 7 days p H value and occult reaction. Results: The p H value of gastric juice increased from 5.07 ± 0.70 before Losec to 5.06 ± 0.78 (P <0.01). There was no significant difference between Losec intravenous injection and gastric tube injection (P> 0.05). There was significant difference between Losec group and cimetidine group (P <0.01). Intravenous injection of Losec was the same as that of intragastric injection of prophylactic ulcer for preventing cerebral hemorrhage. The total effective rate was 90.48%, and the effective rate was 65% in the cimetidine group, P <0 .0 5. Conclusion: Losec can effectively prevent cerebral hemorrhage complicated with stress ulcer bleeding.