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采用大鼠全脑缺血模型，观测脑缺血再灌流脑组织钙依赖性中性蛋白酶（ｃａｌｃｉｕｍ－ａｃｔｉｚａｔｅｄｍｅｕｔｕａｌｐｒｏｔｅｉｍａｓｅ，ｃａｌｐａｉｎ）活性的变化及海马ＣＡ１区神经元损害改变。结果显示脑缺血再灌流脑组织ｃａｌｐａｉｎⅠ和ｃａｌｐａｉｎⅡ活性都明显升高（Ｐ＜０．０１），ＣＡ１区神经元密度相应下降，提示ｃａｌｐａｉｎｓ在脑缺血损害过程中可能起一定作用。
The model of global cerebral ischemia in rats was used to observe the changes of calcium-dependent proteinase (calpain) activity and neuronal damage in hippocampal CA1 area of cerebral ischemia-reperfusion rats. The results showed that the activity of calpain Ⅰ and calpain Ⅱ were significantly increased (P <0.01), the density of neurons in CA1 decreased correspondingly, suggesting that calpains might play a role in the process of cerebral ischemia.