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目的探讨艾滋病病毒感染者/艾滋病病人(HIV/AIDS病人)与高危型人乳头瘤病毒(HPV)感染的相关性,为HIV/AIDS病人宫颈癌的防治研究提供线索和依据。方法将2009年4月至2010年5月,就诊于广州市第八人民医院的34例HIV/AIDS病人的36次高危型HPV检测结果,与33例非HIV感染者的34次高危型HPV检测结果进行对比分析。结果 HIV/AIDS病人感染高危型HPV的风险远高于非HIV感染者,34例HIV/AIDS病人中,有16例高危型HPV检测为阳性(占47.05%),33例非HIV感染者中,有5例高危型HPV检测为阳性(占15.15%),HIV/AIDS病人与非HIV感染者高危型HPV感染的概率差异有统计学意义(P<0.01)。结论 HIV/AIDS病人感染高危型HPV的风险,可能与其CD4+T淋巴细胞数、CD4+/CD8+比值及AIDS的分期有关。应将HIV阳性妇女视作高危人群,常规进行高危型HPV筛查。
Objective To investigate the relationship between HIV / AIDS patients and high-risk human papillomavirus (HPV) infection and to provide clues and evidences for the prevention and treatment of cervical cancer in HIV / AIDS patients. Methods From April 2009 to May 2010, 36 high-risk HPV tests of 34 HIV / AIDS patients attending Guangzhou Eighth People’s Hospital were compared with 34 high-risk HPV tests of 33 non-HIV infected patients The results of comparative analysis. Results The risk of HIV / AIDS patients being infected with high-risk HPV was much higher than that of non-HIV-infected patients. Of 34 HIV / AIDS patients, 16 were high-risk HPV positive (47.05%), 33 were non- There were 5 cases of high-risk HPV test positive (15.15%), the difference of the probability of high-risk HPV infection between HIV / AIDS patients and non-HIV infected persons was statistically significant (P <0.01). Conclusion The risk of high-risk HPV infection in HIV / AIDS patients may be related to CD4 + T lymphocyte count, CD4 + / CD8 + ratio and AIDS staging. HIV-positive women should be considered as at-risk populations and should be routinely screened for high-risk HPV.