目的:建立雷公藤提取物中乙酸乙酯残留量的测定方法。方法:采用顶空毛细管气相色谱法,色谱柱ZB-WAX石英毛细管色谱柱,柱温:100℃;载气:N_2;顶空瓶平衡温度80℃;顶空瓶平衡时间30 min;FID检测器进样体积1ml。结果:乙酸乙酯的线性关系良好;平均回收率为108.9%(RSD为37%)n=9。结论:本法、快速、灵敏度高,适用于雷公藤提取物中乙酸乙酯残留量的测定。 Objective: To establish a method for the determination of ethyl acetate residues in Tripterygium wilfordii extract. Methods: Headspace capillary gas chromatography (GC-MS) and column ZB-WAX quartz capillary column were used. The column temperature was 100 ℃, the carrier gas was N2, the headspace bottle temperature was 80 ℃, the headspace bottle balance time was 30 min. Injection volume of 1ml. Results: The linear relationship of ethyl acetate was good; the average recovery was 108.9% (RSD 37%) n = 9. Conclusion: This method is rapid, sensitive and suitable for the determination of ethyl acetate residues in Tripterygium wilfordii extract.