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目的探讨血管内皮生长因子C(VEGF-C)、CD105和Ras同源蛋白C(RhoC)mRNA在胃癌组织中的表达及其与淋巴结转移的关系。方法采用实时荧光定量逆转录-聚合酶链反应(Real-time PCR)检测62例胃癌组织及62例癌旁周围组织中VEGF-C、CD105和RhoC的表达。结果 VEGF-C mRNA在胃癌组织中的表达量(0.367±0.073)显著高于癌旁正常胃组织(0.121±0.058),P<0.01。胃癌组织中VEGF-C蛋白阳性表达率为53.2%(33/62)显著高于癌旁正常胃组织中阳性表达率8.1%(5/62),P<0.01。胃癌组织中VEGF-C mRNA及蛋白的表达与有无淋巴结转移、TNM不同分期差异有统计学意义(P<0.01),而与性别、年龄、肿瘤直径、分化程度、浸润深度差异无统计学意义(P>0.05)。CD105 mRNA在胃癌组织中的表达量(0.419±0.072)显著高于癌旁正常胃组织(0.214±0.058),P<0.01。胃癌组织中CD105蛋白的阳性表达率为88.1%(52/62)显著高于癌旁正常胃组织中的阳性表达率11.3%(7/62),P<0.01。胃癌组织中CD105 mRNA及蛋白的表达与浸润深度、有无淋巴结转移、TNM不同分期差异有统计学意义(P<0.01),而与性别、年龄、肿瘤直径、分化程度差异无统计学意义(P>0.05)。RhoC mRNA在胃癌组织中的表达量(1.122±0.211)显著高于癌旁正常组织(0.868±0.199),P<0.01。胃癌组织中Rho C蛋白阳性表达率为75.8%(47/62)显著高于癌旁正常胃组织中阳性表达率22.6%(14/62),P<0.01。胃癌组织中RhoC mRNA及蛋白的表达与浸润深度、有无淋巴结转移、TNM不同分期差异有统计学意义(P<0.01),而与性别、年龄、肿瘤直径、分化程度差异无统计学意义(P>0.05)。结论 VEGF-C、CD105和Rho C可能在胃癌的发生、发展和淋巴结转移中发挥重要作用。
Objective To investigate the expression of vascular endothelial growth factor C (VEGF-C), CD105 and Ras homoclonal protein C (RhoC) mRNA in gastric carcinoma and their relationship with lymph node metastasis. Methods The expression of VEGF-C, CD105 and RhoC in 62 cases of gastric cancer tissue and 62 cases of adjacent tissues were detected by Real-time PCR. Results The expression of VEGF-C mRNA in gastric cancer tissue was significantly higher than that in normal gastric tissue (0.367 ± 0.073, 0.121 ± 0.058, P <0.01). The positive rate of VEGF-C protein expression in gastric cancer tissues was 53.2% (33/62), which was significantly higher than that in the adjacent normal gastric tissues (8.1%, P <0.01). There were significant differences in the expression of VEGF-C mRNA and protein in gastric cancer tissues with or without lymph node metastasis and TNM staging (P <0.01), but no significant difference with gender, age, tumor diameter, differentiation degree and depth of invasion (P> 0.05). The expression of CD105 mRNA in gastric cancer tissues (0.419 ± 0.072) was significantly higher than that in adjacent normal gastric tissues (0.214 ± 0.058), P <0.01. The positive rate of CD105 expression in gastric cancer tissues was 88.1% (52/62), which was significantly higher than that in normal gastric tissues (11.3%, 7/62) (P <0.01). There were significant differences in the expression of CD105 mRNA and protein, depth of invasion, lymph node metastasis and TNM staging in gastric cancer (P <0.01), but not in gender, age, tumor diameter and differentiation > 0.05). The expression of RhoC mRNA in gastric cancer tissues (1.122 ± 0.211) was significantly higher than that in adjacent normal tissues (0.868 ± 0.199), P <0.01. The positive rate of Rho C protein expression in gastric cancer tissue was 75.8% (47/62), which was significantly higher than that in adjacent normal gastric tissue 22.6% (14/62), P <0.01. There were significant differences in the expression of RhoC mRNA and protein, the depth of invasion, lymph node metastasis and TNM staging in gastric cancer (P <0.01), but not with the gender, age, tumor diameter and differentiation > 0.05). Conclusion VEGF-C, CD105 and RhoC may play an important role in the carcinogenesis, development and lymph node metastasis of gastric cancer.