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血管紧张素转换酶抑制剂(ACEI)引起顽固性干咳的发生率可高达5～15％(Kaufman J Chest,1989;95:544～48)。本作者近一年中发现11例由ACEI引起咳嗽的药物副反应。11例均为高血压病患者,女性10例,男性1例,年龄52～75岁。致咳药物为:复方卡托普利8例(常州制药厂产,内含巯甲丙脯酸10mg,双克6mg),1,tid;开抟通2例(施贵宝药厂),12.5mg,tid;依那普利1例(常州制药厂),10mgqd。咳嗽的临床特点为:(1)多发生在服药后的1～2周,呈刺激性干咳;(2)停药后1d～14d咳嗽自行消失;反复服药,又反复咳嗽;(3)11例中无慢支史,无同时伴发急性呼吸道疾病;(4)女性占极大多数。
Angiotensin-converting enzyme inhibitors (ACEIs) cause refractory dry coughs up to 5-15% (Kaufman J Chest, 1989; 95: 544-48). In the recent year, the authors found 11 side effects of cough caused by ACEI. Eleven patients were hypertensive patients, 10 females, 1 males, aged 52 to 75 years. Cough medicine: compound captopril in 8 cases (Changzhou Pharmaceutical Factory, containing captopril 10mg, 6 grams of double grams), 1, tid; open pass 2 cases (Shi Guobao pharmaceutical), 12.5mg, 1 case of enalapril (Changzhou Pharmaceutical Factory), 10mgqd. The clinical features of cough were as follows: (1) 1 to 2 weeks after taking the drug was irritating dry cough; (2) the cough disappeared on the 1st to 14th day after taking the medicine; repeated taking medicine and cough repeatedly; (3) 11 cases No history of chronic bronchitis, no concurrent with acute respiratory diseases; (4) Women account for the vast majority.