目的研究消化性溃疡、慢性胃炎（急性活动期）、胃癌患者血浆内皮素－１水平的变化意义．方法采用放射免疫分析法测定了胃溃疡１４例，十二指肠溃疡９例治疗前后及胃炎１５例（急性活动期），胃癌１５例空腹血浆内皮素－１水平，并与１６例健康人作对照．结果胃溃疡（６２９６±２００１ｎｇ／Ｌ），十二指肠溃疡（４５５８±１６５７ｎｇ／Ｌ），慢性胃炎（４５７６±１８７４ｎｇ／Ｌ）及胃癌（４９８２±１３６８ｎｇ／Ｌ）患者血浆内皮素－１水平较对照组（２９７０±９２７ｎｇ／Ｌ）显著升高（Ｐ＜００１）．胃溃疡组（活动期）血浆内皮素＿１水平又明显高于十二指肠溃疡（活动期）胃炎组（Ｐ＜００５）．治疗后胃溃疡组血浆内皮素＿１水平显著下降（Ｐ＜００５）．结论血浆内皮素＿１可能参于胃病的病理生理过程 Objective To study the significance of the changes of plasma endothelin-1 in patients with peptic ulcer, chronic gastritis (acute active phase) and gastric cancer. Methods Radioimmunoassay was used to determine the gastric ulcer in 14 cases, duodenal ulcer in 9 cases before and after treatment and gastritis in 15 cases (acute active stage), gastric cancer 15 cases of fasting plasma endothelin - 1 levels, and 16 cases of healthy people Control. Results Gastric ulcer (6296 ± 2001ng / L), duodenal ulcer (4558 ± 1657ng / L), chronic gastritis (4576 ± 1874ng / L) and gastric cancer 82 ± 1368ng / L) was significantly higher than that of the control group (2970 ± 927ng / L) (P <001). The level of endothelin-1 in gastric ulcer group (active phase) was significantly higher than that of gastritis group in duodenal ulcer (active phase) (P <005). After treatment, the level of endothelin-1 in gastric ulcer group was significantly decreased (P <005). Conclusion Plasma endothelin-1 may be involved in the pathophysiology of gastric diseases