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曾报告心肌梗塞发生于大剂量IVIG 治疗之后。作者乃研究IVIG 影响血流的因素。体外试验:取4例健康人EDTA 抗凝血、离心并吸出血浆至浓集细胞体积(PCV)为70%。以自体同源血浆溶解冻干IVIG 制剂(含Ig 6克和蔗糖10克)至52g/l;继而与血浆以不同比例混合得到含Ig0,2.5,5.10,20和40g/l 血浆;将计算好的含IVIG血浆加到PCV 70%的全血中至PCV 为45%。离心测其实际PCV。血浆(P45)中RBC 粘度在37℃和剪率87.10,2,0.87和0.1/s 下测定。血浆粘度在剪率87,34.6和10.2/s 下测定。计算出平均值。同时用透析去蔗糖的IVIG 和单用蔗糖进行同样试验。蔗糖浓度分别相当于前述给予的IVIG 中含有的。结果随加入正常血浆的Ig 浓度的增加血浆粘度增加(r=0.93 P<0.05).高剪率(87/s)血液粘度亦然,而且在加40g/L 时粘度几乎增加2倍(r=0.976,P
Myocardial infarction has been reported to occur after high-dose IVIG therapy. The authors study the factors that influence IVIG blood flow. In Vitro Assay: EDTA-anticoagulated blood was taken from 4 healthy people, centrifuged and the plasma was aspirated to a concentration of concentrated cell volume (PCV) of 70%. The lyophilized IVIG preparation (Ig 6 g and sucrose 10 g) was dissolved in autologous plasma to 52 g / l; then mixed with plasma at different ratios to give Ig0, 2.5, 5.10, 20 and 40 g / l of plasma; Of IVIG containing plasma was added to 70% of PCV in whole blood to 45% of PCV. Centrifuge the actual PCV. RBC viscosity in plasma (P45) was determined at 37 ° C and at a shear rate of 87.10, 2, 0.87 and 0.1 / s. Plasma viscosity was measured at a shear rate of 87, 34.6 and 10.2 / s. Calculate the average. The same experiment was performed with dialyzed sucrose IVIG and sucrose alone. Sucrose concentrations correspond to those contained in the IVIG administered as above. Results The plasma viscosity increased with the increase of Ig concentration in normal plasma (r = 0.93 P <0.05), and the blood viscosity of high shear rate (87 / s) was also increased. 0.976, P