Ｗｏｏｌｆ指出 ,当反复施加伤害刺激时 ,脊髓会对伤害刺激的阈值降低 ,从而产生过度反应。疼痛持续时就会变成痛觉过敏 ,这已被大鼠的电生理学实验所证实。进一步发现 ,此时脊髓后角的Ｃ纤维反应细胞显著增加 ,提示了神经细胞的可塑性。在Ｗｏｏｌｆ的最初报告中 ,显示了如事 Woolf pointed out that when repeated injury stimulation is applied, the spinal cord will lower the threshold for injury stimulation, resulting in overreaction. Pain persists when it becomes hyperalgesic, which has been confirmed by electrophysiological experiments in rats. Further discovery, at this time the C-fiber response cells in the posterior horn of the spinal cord increased significantly, suggesting that the nerve cell plasticity. In Woolf’s initial report, something went wrong