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目的观察万爽力治疗蒽环类抗肿瘤药物所致心脏毒性的效果与不良反应。方法59例确诊为乳腺癌接受ATG化疗患者,随机分为治疗组30例,对照组29例。所有患者化疗后均出现程度不同的心脏毒性。对照组予常规治疗(大剂量维生素C、维生素E、泛癸利酮),治疗组除常规治疗外另加用万爽力60mg/(kg·d)治疗,两组疗程均为14日。比较两组治疗前、后的心肌酶水平、心肌肌钙蛋白I阳性患者阴转情况以及心电图、UCG的检查结果。结果与治疗前比较,两组治疗后的心肌酶水平均明显下降(均为P<0.01),且治疗后治疗组的心肌酶水平均明显低于对照组(均为P<0.05)。治疗组治疗后的心电图及心肌肌钙蛋白I异常的改善情况亦优于对照组。两组治疗前后的左心室射血分数、左心室短轴缩短百分率、E/A均在正常范围.比较差异均无统计学意义,均为P>0.05。结论对于蒽环类抗肿瘤药物引起的心脏毒性,万爽力对心肌酶谱和心电图异常的改善程度均较常规治疗明显。
Objective To observe the effects and adverse reactions of Wanshuangli on the cardiotoxicity induced by anthracycline antitumor drugs. Methods Fifty-nine patients diagnosed as breast cancer receiving ATG chemotherapy were randomly divided into treatment group (n = 30) and control group (n = 29). All patients showed varying degrees of cardiotoxicity after chemotherapy. The control group was given conventional treatment (high-dose vitamin C, vitamin E, ubidecyl ketone), the treatment group plus conventional treatment plus Wan Shuangli 60mg / (kg · d) treatment, the two courses were 14 days. The levels of myocardial enzymes before and after treatment were compared between the two groups, and the negative conversion of cardiac troponin I-positive patients and the results of electrocardiogram and UCG examination. Results Compared with those before treatment, the levels of myocardial enzymes in both groups were significantly decreased (all P <0.01), and the levels of myocardial enzymes in the treatment group were significantly lower than those in the control group (all P <0.05). Electrocardiogram and cardiac troponin I abnormality in the treatment group after treatment were also better than the control group. The left ventricular ejection fraction and the shortened percentage of left ventricular short axis before and after treatment in both groups were in the normal range, with no significant difference (P> 0.05). Conclusions For the cardiotoxicity induced by anthracycline antitumor drugs, Wanzhuangli’s improvement of myocardial enzymes and ECG abnormalities are more obvious than conventional treatment.