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目的:研究系膜增生性肾小球肾炎(MsPGN)肾组织中活化核因子-κBp65、IL-1β及IL-4基因表达的意义,探讨MsPGN的发病机制。方法:应用原位杂交技术分别检测正常对照组9例与病例组41例MsPGN肾组织中NF-κBp65mRNAI、L-1βmRNA及IL-4 mRNA水平,并分析3项检测指标之间的相互关系及其与MsPGN病变程度的关系。结果:(1)正常对照组中肾小球系膜区活化NF-κBp65mRNA、IL-1DmRNA阳性检出率分别为11.1%、33.3%,而IL-4 mRNA为0;病例组3项检测指标阳性率分别为70.7%、75.6%、61.1%。2组肾小球中3项检测指标阳性率差异有统计学意义(P<0.05)。(2)MsPGN肾小球组织中NF-κBp65mRNA活化与IL-1βmRNA之间呈显著正相关(r=0.383 6,P<0.05),IL-1βmRNA与IL-4mRNA之间亦呈显著正相关(r=0.477 1,P<0.01)。(3)活化NF-κBp65mRNAI、L-1βmRNA及IL-4mRNA阳性率均随着病变程度加重增高,但差异无统计学意义。(4)正常肾组织及MsPGN的肾小管中3项指标检测结果无一定规律性。结论:3项指标在MsPGN发病环节中共同起着作用。MsPGN对致病原的反应更接近于Th2反应。
Objective: To investigate the significance of the expression of activated nuclear factor-κBp65, IL-1β and IL-4 in mesangial proliferative glomerulonephritis (MsPGN) kidney and explore the pathogenesis of MsPGN. Methods: The levels of NF-κBp65mRNAI, L-1βmRNA and IL-4 mRNA in 9 cases of MsPGN nephridial tissue were detected by in situ hybridization, and the relationship between the three indicators and their correlation Relationship with the severity of MsPGN lesions. Results: (1) The positive rates of NF-κBp65mRNA and IL-1DmRNA in glomerular mesangial area in normal control group were 11.1% and 33.3%, respectively, while IL-4 mRNA was 0; 3 cases in test group were positive The rates were 70.7%, 75.6% and 61.1% respectively. There were significant differences in the positive rate of the three detection indexes in glomeruli between the two groups (P <0.05). (2) There was a significant positive correlation between the activation of NF-κBp65mRNA and IL-1βmRNA in MsPGN glomerular tissue (r = 0.383 6, P <0.05), IL-1βmRNA and IL- = 0.477 1, P <0.01). (3) The positive rate of NF-κBp65mRNAI, L-1βmRNA and IL-4mRNA increased with the degree of lesion, but the difference was not statistically significant. (4) There was no regularity in the test results of the three indexes in normal renal tissues and renal tubules of MsPGN. Conclusion: Three indicators play a role in the pathogenesis of MsPGN. The response of MsPGN to pathogens is closer to the Th2 response.