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目的探讨人乳头瘤病毒(HPV)多重感染与宫颈病变之间的关系。方法收集2014年2月-2015年2月在医院妇科门诊接受宫颈液基细胞检查且经检查存在细胞学异常的453例患者的宫颈细胞标本(设为异常组)进行研究,并从同期在医院妇科门诊接受宫颈液基细胞检查且经检查未发现细胞学异常的女性中随机选择138例设为对照组,通过检测和比较对不同宫颈病变类型组的HPV多重感染情况进行分析。结果对照组138例中42例HPV阳性,阳性率为30.4%;异常组中406例为HPV阳性,阳性率为89.6%。异常组不同病变组的阳性率随着病变级别的上升呈现出不断增加的情况,且对异常组不同病变组的阳性率与对照组进行比较差异均有统计学意义(P<0.05)。448例HPV阳性患者中属于单一感染248例,多重感染200例;随着合并感染型别数的不断增加,多重感染比例呈现出不断下降的情况。HPV多重感染的比例在宫颈鳞癌组以外的其他病变组中均随患者宫颈病变级别的上发生呈现出不断增加的情况,且各病变组与对照组比较差异均有统计学意义(P<0.05)。结论 HPV多重感染与宫颈病变的发生之间具有一定的关系。
Objective To investigate the relationship between multiple human papillomavirus (HPV) infection and cervical lesions. Methods From March 2014 to February 2015, cervical cytology specimens from 453 patients with cervical cytology detected in the gynecology outpatient department of the hospital and examined for cytological abnormalities were collected (set as abnormal group), and from the same period in the hospital Women in gynecology clinics who underwent cervical liquid-based cell examination and randomly selected 138 women who did not find cytology abnormalities were selected as the control group. HPV infection in different types of cervical lesions was detected and compared by detecting and comparing. Results In the control group, 42 cases of HPV were positive in 42 cases, the positive rate was 30.4%. In the abnormal group, 406 cases were HPV positive, the positive rate was 89.6%. The positive rates of different pathological groups in abnormal group showed increasing with the increase of pathological grade, and there was significant difference between the positive rate of different pathological groups in abnormal group and control group (P <0.05). Of the 448 HPV-positive patients, 248 cases were single infection and 200 cases were multiple infections. As the number of combined infection types increased, the proportion of multiple infections showed a declining trend. The proportion of multiple HPV infection in patients with cervical squamous cell carcinoma other than the lesion group with the incidence of cervical lesions showed an increasing situation, and the lesion group compared with the control group were statistically significant (P <0.05 ). Conclusion There is a certain relationship between HPV multiple infection and cervical lesions.