针对阿洛西林酸(ALPC)生产中存在晶形差、产品聚结的问题,研究了超声波对ALPC晶体形态的影响。首先测定了纯水中的介稳区,分析了超声波影响产品晶习的机理,然后考察了超声波下初始浓度、流加速率和搅拌速率对阿洛西林酸反应结晶过程的影响,从而确定出了最适宜结晶工艺条件。结果表明:超声波可以改善阿洛西林酸产品的晶习、粒度分布并能降低产品聚结程度,实验所得符合厂家的要求。 In order to solve the problem of poor crystallization and product agglomeration in the production of ALPC, the influence of ultrasound on the morphology of ALPC crystals was studied. First, the metastable zone in pure water was measured, and the mechanism of ultrasonic effect on product crystallization was analyzed. Then the effects of initial concentration, flow rate and stirring rate on the reaction and crystallization process of azlocillin were investigated. The most suitable crystallization process conditions. The results show that ultrasonic can improve the crystal habit and particle size distribution of azlocillin acid product and reduce the coalescence degree of the product, and the experimental results meet the requirements of manufacturers.