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目的:探讨3D打印共面模板(3D-printed coplanar template，3D-PCT)辅助CT引导n 125I放射性粒子植入(radioactive n 125I seedimplantation，RISI)治疗胸壁转移瘤的技术方法和临床疗效，并分析剂量学参数对疗效的影响。n 方法:回顾性分析2014年1月—2021年3月于滕州市中心人民医院行3D-PCT辅助CT引导n 125I粒子植入治疗55例胸壁转移瘤临床资料。术前经TPS制定治疗计划，术中在3D-PCT辅助下行n 125I粒子植入，术后第3天复查CT进行术后剂量验证。术后定期复查CT计算局部控制率、总生存(OS)率，并评价患者疼痛缓解情况及相关并发症。采用Log-rank检验、Cox回归行单因素、多因素分析局部控制时间(local control time, LCT)的影响因素，受试者工作特征(ROC)曲线分析剂量学参数预测LCT的临界值。n 结果:55例行3D-PCT辅助CT引导n 125I粒子植入治疗的胸壁转移瘤患者术后1、2、3年OS率为72.7%(40/55)、21.8%(12/55)、16.4%(9/55)；术后3、6、12、24个月局部控制率为96.4%(53/55)、86.5%(45/52)、85.0%(34/40)、91.7%(11/12)。术后GTV、粒子数目、n D90、n D100、n V100、n V150、n V200、CI、EI、HI与术前比较差异均无统计学意义(n P>0.05)；术后n V90较术前降低，差异有统计学意义(n P＝0.006)。单因素Cox回归分析病理分级、n D90、n D100、n V90和n V200对LCT有显著影响(n P0.05)。Log-rank生存分析显示n D90≥127 Gy的患者比n D90 0.05). Compared with postoperativen V90, the postoperative n V90 decreased with a statistically significant difference(n P=0.006). As indicated by the univariate Cox regression analysis, the pathological grade, n D90, n D100, n V90, and n V200had significant effects on the LCT(n P<0.05). Among them, the pathological grade andn D90 were independent influencing factors of the LCT, while the other factors showed no statistically significant difference according to the multivariate Cox regression analysis.The LCT of patients with n D90≥127 Gy was significantly longer than that of patients with n D90<127 Gy (χn 2=16.61, n P=0.000). The pain relief rate was 80.8%(21/26) after three months. Five cases suffered from grade Ⅰ-Ⅱ radioactive dermatitis and one case experienced grade Ⅲ radioactive dermatitis.n Conclusions:The 3D-PCT-assisted CT-guided n 125I radioactive seed implementation can achieve precise and controllable dose and definite efficacy in the treatment of metastatic tumors of chest wall, with few complications.The LCT was remarkably prolonged in the case of n D90≥127 Gy, and n D90 is an independent influencing factor of the LCT.n