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目的探讨手足口病临床特点及合并甲损伤相关因素分析。方法采集2014年3月-2015年9月在郑州市儿童医院感染科临床诊断的69例手足口病患儿的临床资料和粪便标本,采用实时荧光定量PCR法进行肠道病毒核酸检测;于患儿出院后1周,以后每隔2周随访至30周,询问患儿有无甲损伤,并详细记录。结果手足口病致病原以EV71及CA16为主,2种病原共占62.3%(43/69),其次是CA6,占43.5%(30/69)。甲损伤与发热、食欲差、咽喉炎、上呼吸道感染症状、CA16感染、EV71感染及神经系统症状等无明显相关性(P>0.05);甲损伤与口腔疱疹、浅溃疡面,手、足底、臀部斑丘疹、丘疱疹及CA6感染有相关性。结论 CA6已经成为手足口病优势病原;甲损伤可能与多种肠道病毒感染有关。
Objective To investigate the clinical characteristics of hand-foot-mouth disease and analyze the related factors of combined injury. Methods Clinical data and stool samples of 69 HFMD patients diagnosed in Department of Infectious Diseases of Children’s Hospital of Zhengzhou City from March 2014 to September 2015 were collected and detected by real-time fluorescence quantitative PCR. A week after discharge from hospital, followed up every two weeks to 30 weeks, asked whether children with or without injury, and a detailed record. Results The pathogens of HFMD were mainly EV71 and CA16. The two pathogens accounted for 62.3% (43/69), followed by CA6 (43.5%, 30/69). There was no significant correlation between a-damage and fever, poor appetite, pharyngolaryngitis, symptoms of upper respiratory tract infection, CA16 infection, EV71 infection and neurological symptoms (P> 0.05); A was associated with oral herpes, superficial ulcers, , Buttocks rash, mound herpes and CA6 infection. Conclusion CA6 has become the dominant pathogen of hand, foot and mouth disease. A-damage may be related to multiple enterovirus infections.