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戈谢病(Gaucher disease,GD)又称葡萄糖脑苷脂病,是一种常染色体隐性遗传性疾病,为B.葡萄糖脑苷脂酶(B-glucocerebrosidase)活性显著降低或缺乏,导致葡萄糖脑苷脂在单核一巨噬细胞内大量积蓄,并产生相应的临床症状。实验室多以找到戈谢细胞作为诊断依据[1]。类戈谢细胞主要见于慢性粒细胞性白血病、急性早幼粒细胞白血病等,而出现于多发性骨髓瘤的案例未见报道。为进一步了解类戈谢细胞与多发性骨髓瘤,现报道多发性骨髓瘤伴类戈谢细胞明显增多的一例如下。
Gaucher disease (GD), also known as glucocerebrosidosis, is an autosomal recessive disease characterized by a markedly reduced or absent B-glucocerebrosidase activity that leads to glucose brain Glycosides in a large number of mononuclear macrophages accumulate, and produce the corresponding clinical symptoms. Laboratory to find Goatscet cells as the basis for the diagnosis [1]. Gaucher cells are mainly seen in chronic myelogenous leukemia, acute promyelocytic leukemia, etc., and cases of multiple myeloma have not been reported. In order to further understand the genus Gaucher cells and multiple myeloma, multiple myeloma is reported with a group of Gaucher cells increased significantly as an example below.