激活的NK 细胞可裂解多种靶细胞,除肿瘤细胞外尚有原代巨噬细胞、纤维母细胞及胸腺细胞。目前认为NK 细胞在机体肿瘤监视中起一定作用,因此推测存在某种使正常细胞不被杀伤的机制。Trinchieri和Santoli 曾证明人的靶细胞经干扰素处理后,可对NK 细胞的裂解作用产生抵抗力,其中正常的人纤维母细胞所得到的保护远较肿瘤细胞有效得多。因此提出干扰素对正常细胞的保护作用可能是NK 细胞在体内选择性裂解肿瘤细胞的机制之一。为搞清此问题, Activated NK cells can lyse a variety of target cells. In addition to tumor cells, there are primary macrophages, fibroblasts, and thymocytes. At present, it is considered that NK cells play a role in the surveillance of tumors in the body, and it is speculated that there is a mechanism that prevents normal cells from being killed. Trinchieri and Santoli have demonstrated that human target cells are resistant to lysis by NK cells after being treated with interferon, in which normal human fibroblasts are much more protected than tumor cells. It is therefore proposed that the protective effect of interferon on normal cells may be one of the mechanisms by which NK cells selectively lyse tumor cells in vivo. To understand this issue,