蚯蚓,又称地龙,是重要的中药材。早在三千多年前,我国就作为药用,有消炎止痛、活血化瘀、平喘利尿等功效。 科研工作者从80年代初就开始了对蚯蚓的研究,在我国首次从蚯蚓中提取出溶栓激酶。后由国家自然科学基金、国家科委项目资助及横向科技合作,并对蚯蚓有效成分的综合利用进行了系统研究。 围绕蚯蚓进行的十几年研究其主要完成以下科研成果:①通过蚓激酶临床前研究成果鉴定。②“蚯蚓有效组分综合利用工艺技术”研究。③复方中药制剂“溶栓灵”胶囊的研制。④“复合氨基酸营养液”的研制。⑤治疗烧烫伤的外用药研制。经几年的临床实践疗效显著。现已开发的产品有: 1.复方中药制剂“溶栓灵”胶囊 以蚯蚓的大、中分子组分为基础,根据传统中医药学中的血瘀学说及活血化瘀法则,以清代著名医学家王清任的名方“补阳还伍汤”为依据,改变地龙传统的加工入药方法,使传统中华医学的经验与现代生物技术相结合,已制成预防和治疗血栓栓塞性疾病的复方中药制剂“溶栓灵”胶囊,并进行了药理、毒理、药效等一系列试验研究。经北京、广东、山东、新疆以及香港、台湾、东南亚、美国、加拿大等国家或地区数百人内部临床试用,对预防血栓形成及治疗中风后遗症、静脉曲张、高血压及风湿性关节炎等有显著疗效,无任何不 Thistle, also known as earthworm, is an important Chinese herbal medicine. As early as 3,000 years ago, our country was used as a medicine, which has anti-inflammatory and analgesic effects, blood circulation, anti-asthmatic diuresis and other effects. Researchers have started research on earthworms since the early 1980s and extracted thrombolytic kinases from the earthworms for the first time in China. Afterwards, the project was funded by the National Natural Science Foundation of China, the National Science and Technology Commission, and horizontal scientific and technological cooperation, and a systematic study was conducted on the comprehensive utilization of the effective components of alfalfa. More than a dozen years of research focused on wolfberry have mainly completed the following scientific research achievements: 1 Identification of preclinical research results of lumbrokinase. 2 Research on the “composite utilization technology of effective components”. 3 Preparation of Compound Chinese Medicine Preparation “Luo Boling” Capsule. 4 “Development of Compound Amino Acid Nutrient Solution”. 5 treatment of burns for the development of external medicine. After several years of clinical practice significant effect. The products that have been developed include: 1. The “Tuoshuiling” capsule of the compound Chinese medicine preparation is based on the large and medium molecular components of the Chinese wolfberry. According to the theory of blood stasis in the traditional Chinese medicine and the principle of promoting blood circulation and removing blood stasis, the famous medicine of the Qing Dynasty is used. Wang Qingren’s famous recipe for “Yangyang Huanwu Decoction” is based on changing the traditional method of processing and medicine of Dilong, making the traditional Chinese medicine experience combined with modern biotechnology, and has been made into a compound Chinese medicine for the prevention and treatment of thromboembolic diseases. The preparation of the “dissolve thrombolytic” capsule and a series of experimental studies of pharmacology, toxicology, and efficacy were conducted. Hundreds of internal clinical trials in Beijing, Guangdong, Shandong, Xinjiang, Hong Kong, Taiwan, Southeast Asia, the United States, Canada, and other countries have prevented thrombosis and treatment of stroke sequelae, varicose veins, hypertension, and rheumatoid arthritis. Significant effect, nothing