论文部分内容阅读
目的了解幼兔胎粪吸入后肺组织中血栓素B2(TXB2)和6-酮前列环素1α(6—keto-PGF1α)的动态变化。方法将动物分为轻度胎粪吸入组(16 h,24 h,48 h,72 h)、重度胎粪吸入组和对照组,通过气管内灌入胎粪0.6 ml/kg和 4 ml/kg建立轻、重度幼兔胎粪吸入模型;应用右心室穿刺法经压力传感器与日本光电公司生产RM-6000型多道生理记录仪相连,测定右心室收缩压;应用放射免疫法检测肺组织中TW和6-keto-PGF1α含量。结果轻度胎粪吸入组右心室收缩压从胎粪吸入后 16 h升高(2 57± 0. 10 kPa), 24 h达高峰(3. 57± 0.14kPa),72 h恢复正常(1.89± 0. 14 kPa)。重度胎粪吸入组右心室收缩压(4. 36± 0. 14 kPa)明显高于轻度胎粪吸入组和对照组(1.85±0.05 kPa);轻度幼兔胎粪吸入16 h肺组织TXB2(153.80±15.37 pg/ml)和6-keto-PGF1α(117.40±22.88pg/ml)水平开始增高,24h达高峰(36.900±28.80pg/ml;207.20±28.59pg/ml),至72h开始降低( 103.20± ?
Objective To investigate the dynamic changes of thromboxane B2 (TXB2) and 6-keto-prostacyclin-1α (6-keto-PGF1α) in the lung tissue of young rabbits with meconium aspiration. Methods Animals were divided into mild meconium aspiration group (16 h, 24 h, 48 h, 72 h), severe meconium aspiration group and control group. The animals were infused intratracheally with 0.6 ml / kg of meconium and 4 ml / Kg to establish mild and severe rabbit meconium aspiration model; right ventricular puncture by pressure sensor with the Japan photoelectric company produced RM-6000 multi-channel physiological recorder connected to measure the right ventricular systolic pressure; radioimmunoassay detection of lung tissue Middle TW and 6-keto-PGF1α levels. Results Right ventricular systolic pressure in mild meconium aspiration group increased from 16 h after meconium aspiration (257 ± 0. 10 kPa) to peak at 24 h (3. 57 ± 0. 14 kPa), and returned to normal at 72 h .89 ± 0.14 kPa). Right ventricular systolic pressure (4.36 ± 0.14 kPa) in severe meconium aspiration group was significantly higher than that in mild meconium aspiration group and control group (1.85 ± 0.05 kPa); mild infant meconium aspiration 16 h, the levels of TXB2 (153.80 ± 15.37 pg / ml) and 6-keto-PGF1α (117.40 ± 22.88pg / ml) ; 207.20 ± 28.59pg / ml), and began to decrease at 72h (103.20 ±