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人类生理过程呈现24小时的生物节律,其受时钟基因控制和调节。细胞核受体Rev-Erbα是生物钟系统的重要组成部分,不仅是生物钟基因而且是生物钟调节基因,在维持生物节律准确性中发挥着重要作用;同时,Rev-Erbα调节糖代谢、脂质代谢、脂肪形成、纤溶蛋白降解、血管炎症并与其他与能量平衡相关核受体相互作用参与动脉粥样硬化发生发展过程。以往认为Rev-Erbα是一种孤儿受体,但最近发现其配体是血红素,这一发现拓宽了对该基因的理解并使其成为新的药物靶点。本文提出Rev-Erbα作为生物节律、代谢、免疫调节的共同节点,参与代谢疾病和心血管疾病的过程;并就最新研究进展进行了综述。
The human physiological process presents a 24-hour biological rhythm that is controlled and regulated by clock genes. The nuclear receptor Rev-Erbα is an important part of the circadian clock system. Not only the circadian clock but also the circadian clock gene, Rev-Erbα plays an important role in maintaining the biological rhythm accuracy. Meanwhile, Rev-Erbα regulates glucose metabolism, lipid metabolism, Formation, fibrinolytic degradation, vascular inflammation and other nuclear receptors that are involved in energy balance are involved in the development of atherosclerosis. Rev-Erbα was previously considered an orphan receptor, but the recent discovery that its ligand is heme broadens the understanding of the gene and makes it a new drug target. This paper presents Rev-Erbα as a common node of biological rhythms, metabolism and immune regulation involved in metabolic disease and cardiovascular disease process; and reviews the recent research progress.