论文部分内容阅读
以对二茂铁苯甲酸和2-氦基-5-芳基-1,3,4-噻二唑化合物为原料,合成了7个新的二茂铁苯甲酰噻二唑化合物FcL_1~FcL_7.采用IR、~1H NMR和元素分析对化合物进行了表征.用X-Ray单晶衍射测定了化合物FcL_4的晶体结构.电化学研究表明,化合物在电极表面发生可逆的单电子转移,FcL_1~FcL_7对Pb~(2+)和Zn~(2+)都有一定的电化学响应.抗菌活性试验表明FcL_1~FcL_7均对玉米禾谷镰刀菌有较好的抑菌活性和选择性.抗癌活性试验表明FcL_5~FcL_7对人体食管癌细胞的抑制作用明显.
Seven new ferrocenzoylthiadiazole compounds, FcL_1-FcL_7, were synthesized from ferrocene benzoic acid and 2-henyl-5-aryl-1,3,4-thiadiazole compounds The compounds were characterized by IR, 1H NMR and elemental analysis.The crystal structure of the compound FcL_4 was determined by X-ray single crystal diffraction.Electrochemical studies showed that the compound had reversible one-electron transfer on the surface of electrode, and FcL_1 ~ FcL_7 Both Pb 2+ and Zn 2+ have certain electrochemical response.The antibacterial activity test showed that all of FcL_1 ~ FcL_7 had good antibacterial activity and selectivity against Fusarium graminearum in corn. Experiments show that the inhibitory effect of FcL_5 ~ FcL_7 on human esophageal cancer cells is obvious.