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目的探讨硝苯地平缓释片联合依那普利治疗老年冠心病合并高血压患者的临床效果。方法 90例老年冠心病合并高血压患者,通过数字随机原则分为对照组和实验组,各45例。全部患者均给予基础治疗,对照组患者在基础治疗的同时采用尼群地平、氢氯噻嗪、硝酸异山梨酯联合治疗,实验组患者在基础治疗的同时采用硝苯地平缓释片联合依那普利治疗。对比两组疗效。结果实验组和对照组患者的临床治疗总有效率分别为91.1%和75.6%,比较差异有统计学意义(P<0.05);两组患者治疗前收缩压(SBP)、舒张压(DBP)比较差异无统计学意义(P>0.05);治疗后两组患者的SBP和DBP均显著低于治疗前,实验组SBP、DBP显著低于对照组(P<0.05)。结论临床对老年冠心病合并高血压患者进行治疗时,硝苯地平缓释片联合依那普利的治疗效果比较明显,能显著改善患者的血压水平,值得临床推广和应用。
Objective To investigate the clinical effects of nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients with coronary heart disease complicated with hypertension. Methods 90 cases of elderly patients with coronary heart disease and hypertension were divided into control group and experimental group by digital randomization principle, 45 cases each. All patients were given basic treatment. Patients in the control group were treated with nitrendipine, hydrochlorothiazide and isosorbide dinitrate at the same time. Patients in the experimental group were treated with nifedipine sustained-release tablets combined with enalapril . Compare two groups curative effect. Results The total effective rate of clinical treatment in experimental group and control group was 91.1% and 75.6%, respectively, with statistical significance (P <0.05). The SBP and DBP in both groups were significantly higher than those before treatment There was no significant difference between the two groups (P> 0.05). After treatment, SBP and DBP in both groups were significantly lower than those before treatment, SBP and DBP in the experimental group were significantly lower than those in the control group (P <0.05). Conclusion Clinical treatment of elderly patients with coronary heart disease complicated with hypertension, nifedipine sustained-release tablets combined with enalapril treatment effect is more obvious, can significantly improve the patient’s blood pressure level, it is worthy of clinical promotion and application.