Jass根据Dukes′分级标准,对肿瘤的分类与组织学变化的各种关系,通过Cox′s回归模型分析认为淋巴结细胞浸润的深度,在与生存期的相关因素预测有其重要意义,但对肿瘤的类型、差异性、生长方式及淋巴细胞的浸润性尚缺乏极好的统一标准。为进一步的深入研究,在Dukes′分级及TNM分期的基础上许多学者进行了定量病理学研究。细胞核的肿胀、DNA、线粒体或倍体的异常,是 According to the Dukes’ grading standard, Jass analyzed the relationship between tumor classification and histological changes, and analyzed the depth of lymph node cell infiltration by Cox’s regression model. It is important to predict the correlation with survival factors, but it is important for tumors. The type, diversity, growth pattern, and infiltration of lymphocytes are still lacking excellent uniform standards. For further study, many scholars conducted quantitative pathology studies based on the Dukes’ classification and TNM staging. Nucleus swelling, DNA, mitochondrial or ploidy abnormalities are