论文部分内容阅读
凋亡细胞内由于组蛋白 ＤＮＡ的稳定性受到破坏或染色质受到修饰 ,使得凋亡细胞的ＤＮＡ对热变性敏感。在适宜条件下 ,凋亡细胞的ＤＮＡ能被热变性为具有足够长度、形成一定构像的单链ＤＮＡ(ｓｉｎｇｌｅ ｓｔｒａｎｄｅｄＤＮＡ ,ｓｓＤＮＡ) ,从而被ｓｓＤＮＡ特异的单克隆
Apoptotic cells are susceptible to thermal denaturation due to the destruction of histone DNA stability or the modification of chromatin in apoptotic cells. Under appropriate conditions, DNA from apoptotic cells can be thermally denatured into single-stranded DNA (ssDNA) of sufficient length to form a conformation and thereby be ssDNA-specific monoclonal