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目的:探讨P16在不同宫颈病变组织中的表达及在临床诊断中的应用价值。方法:选择慢性宫颈炎19例,各级别宫颈上皮内瘤变(CIN)89例(CINⅠ35例,CINⅡ30例,CINⅢ24例)及宫颈鳞状细胞癌7例,采用免疫组化技术检测P16在各组患者的表达水平。结果:P16在慢性宫颈炎、CINⅠ、CINⅡ、CINⅢ及宫颈鳞状细胞癌组患者的阳性表达率分别为0.00%、40.00%、66.67%、70.83%、100.00%,随宫颈病变程度的升级P16蛋白的表达率及阳性表达强度均逐渐上升,差异有统计学意义(P<0.05)。结论:P16用于鉴别不同级别宫颈上皮内瘤变指异临床诊疗有重要价值。
Objective: To investigate the expression of P16 in different cervical lesions and its clinical value. Methods: Nineteen cases of chronic cervicitis, 89 cases of cervical intraepithelial neoplasia (CIN), 35 cases of CINⅡ, 24 cases of CINⅡ and 24 cases of cervical squamous cell carcinoma were included in this study. Immunohistochemistry was used to detect the expression of P16 in each group Patient’s level of expression. Results: The positive rates of P16 in patients with chronic cervicitis, CINⅠ, CINⅡ, CINⅢ and cervical squamous cell carcinoma were 0.00%, 40.00%, 66.67%, 70.83% and 100.00%, respectively. The positive rate of P16 protein The expression rate and the positive expression intensity gradually increased, the difference was statistically significant (P <0.05). Conclusion: P16 is of great value in differentiating different clinical levels of cervical intraepithelial neoplasia.