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本文采用不同剂量伊曲康唑间歇冲击疗法治疗２２例甲真菌病患者，并用高压液相色谱法（ＨＰＬＣ）测定了伊曲康唑在甲板中的浓度。结果表明：４００，３００，２００ｍｇ·ｄ－１三个不同剂量组，服药后１周即可在指、趾甲远端测出药物，停药后６个月仍可在甲板中测到高于ＭＩＣ的浓度。证明药物进入甲板有两条途径：一是通过甲床迅速弥散；二是与甲母细胞结合后进入。药物进入指甲的速度较进入趾甲为快，甲板中药物的浓度与口服药物的剂量呈正相关，４００ｍｇ组明显高于２００ｍｇ组。
In this paper, different doses of itraconazole intermittent impact therapy for the treatment of 22 cases of onychomycosis patients, and determination of the concentration of itraconazole in the deck by high pressure liquid chromatography (HPLC). The results showed that three doses of 400, 300, and 200 mg · d-1 could be detected at the distal end of finger and toe nails one week after taking the drug. concentration. Demonstrate the drug into the deck has two ways: First, through the rapid diffusion of nail bed; second is combined with a mother cell into the. Drug into nails faster than into the nail, the concentration of drugs in the deck and the dose of oral drugs was positively correlated, 400mg group was significantly higher than the 200mg group.