50年前施贵宝将箭毒制品一简箭毒碱引进麻醉临床中，使神经肌肉传导阻断而肌肉松弛，从而避免使用大剂量挥发性麻醉药及深麻醉，使患者更加安全和舒适，麻醉操作更简便，术后恢复加快，在麻醉方面发生了一场大变革。多年来已生产出多种合成药物。早期对双季按盐构效关系的研究 Fifty years ago, Bristol-Myers Squibb introduced the arrowhead poison-free rodenticide into the anesthetic clinical practice, blocking neuromuscular blockade and muscle relaxation, thereby avoiding the use of high-dose volatile anesthetics and deep anesthesia to make patients safer and more comfortable. Easier, faster recovery after surgery, a major change in anesthesia. Over the years have produced a variety of synthetic drugs. Study on the Structure - Activity Relationship of Salt in Early Seasons