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已有研究表明,孕期母体天然杀伤细胞(NK)和抗体依赖性细胞介导的细胞毒性(ADCC)等细胞免疫功能降低,而产后ADCC活性升高。NK和ADCC活性都由大颗粒淋巴细胞(LGLs)介导,LGLs也显示细胞毒性T淋巴细胞活性。因此认为细胞形态学可以反映其溶解活性。关于妊娠及产后妇女LGLs的报道尚少,作者对此进行了研究。研究对象包括:①82例健康孕妇,其中孕早期(7～13周)24例、孕中期(14～27周)26例、孕晚期(28～41周)32例;②61例健康产后妇女:25例属产后第1月,16例属第4月,20例属第7月;
Studies have shown that maternal natural killer cells (NK) and antibody-dependent cell-mediated cytotoxicity (ADCC) during pregnancy reduce cellular immune function, while postnatal ADCC activity increased. Both NK and ADCC activities are mediated by large granulocyte lymphocytes (LGLs), which also show cytotoxic T lymphocyte activity. Therefore, cell morphology is considered to reflect its lytic activity. There are few reports on LGLs in pregnant and postpartum women, and the authors studied this. The study included: (1) 82 healthy pregnant women, including 24 in the first trimester (7-13 weeks), 26 in the second trimester (14-27 weeks) and 32 in the second trimester (28-41 weeks) Cases are the first month after delivery, 16 cases belong to the first 4 months, 20 cases belong to the first 7 months;