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醛缩酶(Aldolase,ALD)是糖酵解过程中的一个重要酶类,与葡萄糖和果糖的代谢有密切关系,与糖原的异生作用亦有关,分子量160,000,能催化以果糖-1,6-二磷酸(fructose diphosphate,FDP)和果糖-1-磷酸(FIP)为底物的裂解。以FDP为底物的醛缩酶称为FDP醛缩酶,以FIP为底物的醛缩酶称为FIP醛缩酶。前者在骨骼肌中活力最高,后者主要存在于肝及肾组织中。应用醋酸纤维素膜电泳测定显示人类和哺乳动物组织中存在3种醛缩酶同功酶,即肌肉型醛缩酶同功酶(ALD-A)、肝型醛缩酶同功酶(ALD-B)和脑型醛缩酶同功酶(ALD-C)。近年来,国外应用放射免疫测定法对ALD-A在肝病、某些肌肉病变、各种消化
Aldolase (ALD) is an important enzyme in the glycolysis process. It is closely related to the metabolism of glucose and fructose, and also related to the gluconeogenic effect. It has a molecular weight of 160,000 and can catalyze fructose-1, The cleavage of 6-diphosphate (fructose diphosphate, FDP) and fructose-1-phosphate (FIP) is the substrate. The aldolase with FDP as substrate is called FDP aldolase, and the aldolase with FIP as substrate is called FIP aldolase. The former has the highest vitality in skeletal muscle, and the latter mainly exists in liver and kidney tissues. Cellulose acetate membrane electrophoresis showed that there are three aldolase isoenzymes in human and mammalian tissues, namely, muscle-type aldolase isoenzyme (ALD-A) and liver-type aldolase isoenzyme (ALD-). B) and brain aldolase isoenzyme (ALD-C). In recent years, foreign application of radioimmunoassay on ALD-A in liver disease, certain muscle diseases, various digestion