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目的 观察地尔硫 艹卓 与美托洛尔联合治疗混合型心绞痛的疗效及安全性。方法 选择 31例常规口服阿斯匹林 ,硝酸酯类 ,美托洛尔 2周疗效不好的混合型心绞痛患者 ,后两周加用地尔硫 艹卓 ,采用自身前后对照方法 ,共 4周 ,观察心绞痛症状 ,心电图及心功能的变化。结果 (1)合用地尔硫 艹卓 后心绞痛发作次数明显减少 ,持续时间明显缩短。 (2 )缺血性ST -T明显改善。 (3)加用地尔硫 艹卓 前后心功能无显著性变化。(4 )出现 2例窦性心动过缓 ,经调整用药后恢复。结论 混合型心绞痛患者联合应用地尔硫 艹卓 及美托洛尔是安全有效的。
Objective To observe the efficacy and safety of diltiazem and metoprolol in the treatment of mixed angina pectoris. Methods A total of 31 patients with mixed angina pectoris who were treated with aspirin, nitrates and metoprolol for 2 weeks were enrolled in this study. Diltiazem was added in the last two weeks, Observe the changes of angina pectoris, electrocardiogram and cardiac function. Results (1) The combination of diltiazem significantly reduced the number of angina attacks, the duration was significantly shorter. (2) ischemic ST-T was significantly improved. (3) plus Diltiazem before and after cardiac function no significant change. (4) 2 cases of sinus bradycardia, recovery after adjustment. Conclusions Combined use of diltiazem and metoprolol in patients with mixed angina is safe and effective.