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目的探讨抗精子抗体(AsAb)检测、抗子宫内膜抗体(EMAb)检测、抗心磷脂抗体(AcL)检测等免疫性抗体检测对于女性不孕不育的临床意义。方法 1125例女性不孕不育患者作为观察组,同时选择75例健康女性作为对照组,采用酶联免疫吸附测定法(ELISA)检测两组血清中的AsAb、EMAb、AcL,比较两组AsAb、EMAb、AcL阳性率。结果观察组患者抗精子总抗体(AsAb-T)阳性676例、阳性率60.1%,EMAb阳性366例、阳性率为32.5%,Ac L阳性250例、阳性率为22.2%;对照组AsAb-T阳性4例、阳性率5.3%,EMAb阳性4例、阳性率为5.3%,AcL阳性3例、阳性率为4.0%;两组AsAb-T、EMAb、AcL阳性率比较,差异均具有统计学意义(P<0.05)。结论 AsAb、EMAb、AcL是女性不孕不育十分重要的免疫因素,临床治疗女性不孕不育应注重AsAb、EMAb、AcL等免疫性抗体的检测。
Objective To investigate the clinical significance of detection of anti-sperm antibody (AsAb), anti-endometrial antibody (EMAb) and anti-cardiolipin antibody (AcL) in detecting female infertility. Methods A total of 1125 women with infertility were enrolled in this study. 75 healthy women were selected as the control group. Serum AsAb, EMAb and AcL were detected by enzyme-linked immunosorbent assay (ELISA) EMAb, AcL positive rate. Results The positive rate of AsAb-T in the observation group was 676, the positive rate was 60.1%, the positive rate of EMAb was 366, the positive rate was 32.5%, and the positive rate of Ac-L was 250. The positive rate of AsAb-T Positive in 4 cases, the positive rate of 5.3%, EMAb positive in 4 cases, the positive rate was 5.3%, AcL positive in 3 cases, the positive rate was 4.0%; two groups of AsAb-T, EMAb, AcL positive rates, the differences were statistically significant (P <0.05). Conclusions AsAb, EMAb and AcL are important immune factors for infertility in women. As infective sterility should be focused on the detection of AsAb, EMAb and AcL in clinical practice.