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麻醉药物的筛选对优生和预防医学具有重要的意义。因致突变物质对遗传物质的损伤可反映在染色体结构的异常和SCE上,采用细胞遗传学技术检测致突变物是敏感、快速、准确的方法之一。附一医院麻醉科余金甫副教授等人从1981年起以染色体畸变和SCE率为指标,对常用的东茛菪碱、氯丙嗪、普鲁卡因、利多卡因、哌替啶、异丙嗪、琥珀胆碱、苯巴比妥、安定和氯胺酮等10种药物进行致突变性检测,并对其中两项指标明显增高的氯丙嗪和东莨菪碱以小
Screening for narcotic drugs is of great importance for eugenics and preventive medicine. Because of the mutagenic material damage to the genetic material can be reflected in the chromosomal structure abnormalities and SCE, the use of cytogenetic technology to detect mutagens is sensitive, fast and accurate method. Attached to a hospital anesthesiology Yu Jinfu associate professor and others since 1981 to chromosome aberrations and SCE rate as an indicator of commonly used scopolamine, chlorpromazine, procaine, lidocaine, meperidine, promethazine , Succinylcholine, phenobarbital, diazepam and ketamine and other 10 kinds of drugs for mutagenicity test, and two indicators were significantly higher chlorpromazine and scopolamine to small