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目的 :对心肝宝联合促肝细胞生长素 (HGF)治疗慢性乙型肝炎 (CHB)进行临床观察。方法 :74例CHB患者随机分为两组 ,治疗组应用心肝宝联合HGF治疗 ,对照组应用能量合剂保肝治疗 ,观察治疗前后肝功能恢复情况、血清Ⅲ型前胶原 (PCⅢ )、透明质酸 (HA)、Ⅳ型胶原 (Ⅳ C)、层粘连蛋白 (LN)水平及T细胞亚群变化。结果 :治疗组有效率显著高于对照组 (P <0 .0 5 ) ;治疗组治疗后血清PCⅢ、HA、Ⅳ C、LN降低 ;T细胞亚群中CD+ 4 ,CD+ 4 /CD+ 8提高 ,CD+ 8下降 (P <0 .0 5 ) ,对照组治疗前后无变化。结论 :心肝宝联合HGF治疗CHB能提高疗效 ,并有一定的抗纤维化及免疫调节作用。
Objective: To observe the clinical effect of combined hepatoprotective effect of hepatobiliary hepatocyte growth factor (HGF) on chronic hepatitis B (CHB). Methods: A total of 74 CHB patients were randomly divided into two groups. The treatment group was treated with XHXP combined with HGF. The control group was treated with energy mixture and liver protection. The recovery of liver function, serum PC Ⅲ, hyaluronic acid (HA), type Ⅳ collagen (Ⅳ C), laminin (LN) and T cell subsets. Results: The effective rate of the treatment group was significantly higher than that of the control group (P <0.05); the levels of PCⅢ, HA, Ⅳ C and LN in the treatment group were decreased; the levels of CD + 4 and CD 4 + CD 8 were increased in the T cell subsets, CD + 8 decreased (P <0.05), no change in the control group before and after treatment. Conclusion: The treatment of CHB with XHG combined with HGF can improve the curative effect, and has certain anti-fibrosis and immunomodulatory effects.