前已报道,约氏疟原虫子孢子入侵大鼠肝细胞与枯氏细胞的吞噬活性水平呈正相关,而与其异化代谢水平呈负相关。体外试验证明,伯氏疟原虫子孢子可主动侵入小鼠腹腔巨噬细胞 在正常情况下,巨噬细胞很快死亡而子孢子则完好无损,但在免疫血清条件下,巨噬细胞中子孢子迅即退化。大鼠感染伯氏疟原虫急性期,其血清在体外有抑制腹腔巨噬细胞的吞噬作用。以往研究提示红内期感染条件下有可能通过抑制或刺激单核巨噬细胞系统而影响子孢子的入侵。现用对约氏疟原虫子孢子敏感的Wistar大鼠,观察其在感染约氏疟原虫急 It has been previously reported that the phagocytic activity of Plasmodium yoelii sporozoites in rats’ liver cells is positively correlated with the level of phagocytosis, but negatively correlated with the level of their alienation metabolism. In vitro experiments showed that P. berghei sporozoites could invade mouse peritoneal macrophages actively. Under normal circumstances, macrophages died rapidly while sporozoites were intact. However, under the conditions of immune serum, macrophage neutron spores Degenerate quickly. Rats infected with P. berghei acute phase, the serum in vitro inhibition of phagocytosis of peritoneal macrophages. Previous studies suggest that it is possible to affect sporozoite invasion by inhibiting or stimulating the monocyte-macrophage system under the condition of red-phase infection. Wistar rats that are currently susceptible to Plasmodium yoelii sporozoites are observed for their resistance to Plasmodium yoelii