论文部分内容阅读
目的:探讨利用辅助生殖技术卵细胞胞质内单精子显微注射(intracytoplasmic sperm injection,ICSI)妊娠后较高的流产率与胚胎染色体异常的关系。方法:对ICSI妊娠后自然流产(ICSI组)、自然妊娠后自然流产(自然妊娠组)的流产绒毛进行染色体检查,分析流产胚胎的染色体异常情况。结果:ICSI妊娠组44例中,流产胚胎染色体异常率65.9%(29/44),显著高于其他自然流产相关因素(P<0.005);自然妊娠组40例中,流产胚胎染色体异常率57.5%(23/40),显著高于其他自然流产相关因素(P<0.005)。两组的流产胚胎染色体异常率无明显差异(P>0.05)。两组流产胚胎染色体异常共52例,其中染色体数量异常47例(90.4%),ICSI妊娠组占51.1%(24/47),自然妊娠组占48.9%(23/47),组间无差异;染色体结构异常5例(9.6%),全部出现在ICSI组。结论:ICSI妊娠后的高流产率与流产胚胎的染色体异常密切相关,其染色体异常发生率与自然妊娠后流产无明显差异。
OBJECTIVE: To investigate the relationship between high abortion rate and chromosomal abnormalities in embryos after intracytoplasmic sperm injection (ICSI) by assisted reproductive technique. Methods: Chromosomal examination of spontaneous abortion (ICSI group) after spontaneous pregnancy and spontaneous abortion (spontaneous pregnancy) group after ICSI were performed to analyze the chromosomal abnormalities of aborted fetus. Results: Among 44 pregnant women with ICSI, the rate of abortion chromosomal abnormalities was 65.9% (29/44), which was significantly higher than that of other spontaneous abortion (P <0.005). In the 40 cases of spontaneous pregnancy, the abnormal rate of aborted embryos was 57.5% (23/40), which was significantly higher than other factors related to spontaneous abortion (P <0.005). There was no significant difference in chromosomal abnormalities between two groups (P> 0.05). There were 52 cases of chromosomal abnormalities in two groups of abortion embryos, including 47 cases (90.4%) with abnormal chromosome number, 51.1% (24/47) in ICSI pregnancy group and 48.9% (23/47) in spontaneous pregnancy group with no difference. Chromosome structural abnormalities in 5 cases (9.6%), all in the ICSI group. CONCLUSIONS: The rate of high abortion after ICSI pregnancy is closely related to chromosomal abnormalities in aborted fetuses. The incidence of chromosomal abnormalities in ICSI pregnancy is not significantly different from abortion after spontaneous pregnancy.