天然免疫系统是防御微生物感染的第一道防线。近年来的研究发现在天然免疫应答过程中 ,抗原的识别是由Toll蛋白受体家族所介导的 ,具有种属特异性。Toll蛋白家族的受体可识别病原性微生物的保守分子 ,并与信号传导途径相偶联 ,激活大量与免疫应答相关的编码基因 ,最终导致一系列免疫应答的产生 The natural immune system is the first line of defense against microbial infections. In recent years, the study found that in the process of innate immune response, antigen recognition is mediated by the Toll receptor family, which is species-specific. Receptors of the Toll family of proteins recognize conserved molecules of pathogenic microorganisms and are coupled to signal transduction pathways to activate a number of coding genes associated with the immune response that ultimately lead to the generation of a series of immune responses