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应用细胞内生物电记录技术,观察神经肽P物质(SP)对大鼠星状神经节细胞的影响。SP在1μmol~10μmol或更高的浓度范围内,供试35个细胞,有28个细胞发生膜除极反应。用低钙(0.25mm)或用含河豚毒素(TTX,1μmol)克氏液灌流神经节,不影响SP引起的除极反应的幅度和时程。SP引起除极反应的同时常伴有膜电阻增大。当膜电位增大时,除极化反应幅度变小,反转电位为-80mV至-100mV。研究表明,SP对部分星状神经节细胞具有兴奋作用,使通过这些细胞的信息传递增强;SP对细胞膜的除极作用是由于其引起细胞膜钾导降低所致。
The use of intracellular bioelectrical recording technology to observe the neuropeptide substance P (SP) on rat stellate ganglion cells. SP in the concentration range of 1μmol ~ 10μmol or higher for the test of 35 cells, 28 cell membrane depolarization occurred. Perfusion of ganglia with low calcium (0.25 mm) or with tetrodotoxin (TTX, 1 μmol) Krebs did not affect the amplitude and duration of depolarization induced by SP. SP cause depolarization reaction often accompanied by increased membrane resistance. When the membrane potential increases, the amplitude of the depolarization reaction becomes smaller, and the reversal potential is -80 mV to -100 mV. Studies have shown that SP has an excitatory effect on some stellate ganglion cells and enhances the transmission of information through these cells. The depolarization action of SP on the cell membrane is due to the decrease of the potassium conductivity of the cell membrane.