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目的 通过慢性砷中毒病区 15年的长期改水干预后 ,对病区进行流行病学调查及慢性砷中毒患者的转归分析。方法 选择干预前井水砷含量为 0 .6mg/ L 和 0 .5 8mg/ L两地区居民进行随访 ,并进行染色体畸变、微核检查 ,同时以水砷含量 0 .0 3 mg/ L地区居民为对照组。结果 经过长期改水干预后两病区患者中改水 2年仍未愈病例总的好转率为 73 .4% ,轻度患者治愈率达 76.4% ,掌跖角化好转率为 85 .2 % ,色素异常好转率为71.2 %。皮肤癌患者 3例。随访患者中 19例死亡者 14例为癌症。部分患者躯干色素及角化皮疹增多。两病区患者染色体畸变、微核与对照组相比差异有显著意义 (P <0 .0 1)。随访中未发现新病例。结论 改水干预 15年患者有了明显好转 ,较彻底解决了砷中毒的病因。砷对慢性砷中毒患者的进一步远期影响问题有待于今后继续随访及寻找更有效解决方法
Objective To investigate the epidemiological investigation and the prognosis of patients with chronic arsenic poisoning through chronic arsenic poisoning after 15 years of long-term water changing intervention. Methods The residents with arsenic levels of 0. 6 mg / L and 0. 58 mg / L in well water before intervention were selected for follow-up and chromosomal aberration and micronucleus test. At the same time, residents with arsenic content of 0. 03 mg / L For the control group. Results After long-term water diversion, the improvement rate of two cases in two wards was 73.4%, the cure rate of mild patients was 76.4%, and the improvement rate of palmoplantar keratosis was 85.2% , Pigmentation abnormal improvement rate of 71.2%. Skin cancer patients in 3 cases. Of the 19 patients who were followed up, 14 were cancer. Some patients with trunk pigment and keratosis increased. Chromosome aberration in patients with two wards, micronucleus compared with the control group had significant differences (P <0.01). No new cases were found during follow-up. Conclusion The intervention of water for 15 years has been significantly improved in patients with more than completely solve the etiology of arsenic poisoning. Further arsenic in patients with chronic arsenic poisoning problems need to be followed up in the future and to find more effective solutions