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使用ｐ５３突变蛋白单克隆抗体，采用免疫组化ＡＢＣ法，对９３例乳腺癌标本的石蜡包埋切片进行标志，藉此探讨ｐ５３突变蛋白与乳腺癌生物学行为之间的关系，结果显示：ｐ５３突变蛋白在乳腺癌中的阳性率是４７．３１％，非特殊型和特殊型乳腺癌的ｐ５３突变蛋白阳性率分别为４７．６７％和４２．８６％，二者无显著差异。ｐ５３突变蛋白阳性率与肿瘤分期、月经状况以及淋巴转移状况无关。
Immunohistochemical ABC method was used to identify the paraffin-embedded sections of 93 specimens of breast cancer using p53 mutein monoclonal antibody to investigate the relationship between p53 mutant protein and biological behavior of breast cancer. The results showed that: p53 The positive rate of mutated protein in breast cancer was 47.31%. The positive rates of p53 mutated protein in non-specific and specific breast cancer were 47.67% and 42.86%, respectively. There was no significant difference between the two. The positive rate of p53 mutant protein was not related to tumor stage, menstrual status and lymphatic metastasis.