论文部分内容阅读
目的观察尼莫地平联合叶酸治疗伴H型高血压急性脑梗死的临床疗效究。方法选取2015年在本院就诊的H型高血压急性脑梗死病人150例,随机分为治疗组、对照1组、对照2组各50例,比较3组病人治疗前后不同时间点血压、血浆同型半胱氨酸(Hcy),美国国立卫生研究院卒中量表(NIHSS)评分以及Barthel指数的差异。结果治疗组在治疗后3周后收缩压(122.19±10.22)mmHg,低于对照1组的(127.69±9.35)mmHg和对照2组的(126.63±8.96)mmHg,且差异具有统计学意义(P<0.05);治疗组在治疗后3周的舒张压为(71.24±9.15)mmHg低于对照1组(75.39±8.17)mmHg和对照2组(74.28±7.96)mmHg,且差异具有统计学意义(P<0.05);治疗组在治疗后3周的血浆Hcy为(8.12±2.14)μmol/L,低于对照1组的(9.54±1.51)μmol/L和对照2组(9.62±1.78)μmol/L,且差异具有统计学意义(P<0.05);治疗组在治疗后3周的NIHSS评分(11.34±4.83)分,低于对照1组(13.45±5.17)和对照2组(13.62±4.91)分,且差异具有统计学意义(P<0.05);治疗组在治疗后3月的Barthel指数(86.72±12.35),高于对照1组(72.19±10.27)和对照2组(73.62±10.89),且差异具有统计学意义(P<0.05)。结论尼莫地平联合小剂量叶酸能有效控制伴H型高血压急性脑梗死病人的血压水平,降低血浆同型半胱氨酸,改善脑梗死病人预后。
Objective To observe the clinical efficacy of nimodipine combined with folic acid in the treatment of Hypertensive acute cerebral infarction. Methods A total of 150 hypertensive cerebral infarction patients with H-type hypertension treated in our hospital during 2015 were randomly divided into treatment group, control group 1 and control group 2, 50 patients in each group. Blood pressure, Cysteine (Hcy), NIH Stroke Scale (NIHSS) score, and Barthel Index. Results The systolic blood pressure (122.19 ± 10.22) mmHg, (127.69 ± 9.35) mmHg in the control group and 126.63 ± 8.96 mmHg in the control group (2) after 3 weeks of treatment were significantly lower than those in the control group (P <0.05). The diastolic blood pressure of the treatment group at 3 weeks after treatment was (71.24 ± 9.15) mmHg lower than that of the control group 1 (75.39 ± 8.17 mmHg) and the control group 2 (74.28 ± 7.96) mmHg, and the difference was statistically significant (P <0.05). The Hcy in the treatment group was (8.12 ± 2.14) μmol / L at 3 weeks after the treatment, which was lower than that in the control group 1 (9.54 ± 1.51 μmol / L and the control 2 group (9.62 ± 1.78) μmol / L and the difference was statistically significant (P <0.05). The NIHSS score of the treatment group at 3 weeks after treatment was 11.34 ± 4.83, lower than that of control group 1 (13.45 ± 5.17) and control group 2 (13.62 ± 4.91) (P <0.05). The Barthel index (86.72 ± 12.35) in the treatment group after 3 months of treatment was significantly higher than that in the control group 1 (72.19 ± 10.27) and the control group 2 (73.62 ± 10.89), and the difference was statistically significant And the difference was statistically significant (P <0.05). Conclusion Nimodipine combined with low-dose folic acid can effectively control the blood pressure of patients with Hypertension and acute cerebral infarction, reduce plasma homocysteine and improve the prognosis of patients with cerebral infarction.