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选用19只做了左冠状动脉前降支结扎术的家兔,其中12只术后静脉注射硝苯吡啶,为给药组,7只为对照组,术后不给药。两组动物按三个阶段(2～4天;10～28天;49天)杀死。在实验过程中均描记了术前、术后和杀前心电图;并用印度墨汁灌注左、右冠状动脉后,对梗塞区心壁做了厚片观察。对19只家兔的心电图分析结果为:全部家兔术前心电图均属正常;有12只(包括给药组和对照组)动物的术后和杀前心电图均出现明显的病理性改变,但杀前出现了显著的病理变化。而其余6只均属第二阶段杀死的动物,其术后心电图有明显病理改变,但杀前心电图则基本上恢复正常,其中包括给药组4例,对照组2例。两组动物心壁厚片观察结果为:给药组与对照组梗塞区微血管均在术后4天开始出现:随时间推移,两组梗塞区微血管逐渐增多,但给药组动物至第3～4周时微血管生长达到高峰;至第7周则渐趋减少。而对照组动物至第2～3周达到高峰,至第7周微血管口径与第三周者无明显变化。而按阶段将给药组与对照组分别做同期比较时,则显示出给药组动物心壁梗塞区徽血管的增生程度均比对照组有显著差别。通过血管密度的增加及口径的曲线变化表明硝苯吡啶对心壁梗塞区有明显的扩张微血管和改善血液循环的作用,进而进促了梗塞区的病理修复过程。
Twenty-nine rabbits were selected for ligation of the left anterior descending coronary artery. Of them, 12 were given nifedipine intravenously after the operation, and only 7 were given as control group. Two groups of animals were killed in three stages (2-4 days; 10-28 days; 49 days). During the experiment, preoperative, postoperative and pre-ankle electrocardiogram were recorded. After the left and right coronary arteries were infused with Indian ink, a thick film was observed on the infarct wall. The electrocardiogram analysis of 19 rabbits showed that all rabbits had normal preoperative electrocardiogram (ECG); there were 12 pathological changes in postoperative and pre-anterior electrocardiogram (ECG) in 12 rabbits (including administration group and control group) There were significant pathological changes before killing. The remaining 6 were killed in the second phase of the animal, the postoperative ECG obvious pathological changes, but before the pre-kill ECG was returned to normal, including the administration group 4 cases, control group 2 cases. Two groups of animal heart wall thick piece observation results: the administration group and the control group, the microvascular in the infarction area began to appear 4 days after operation: over time, the two groups of infarction area microvascular gradually increased, but the administration group of animals to 3 ~ Microvessel growth peaked at 4 weeks, but decreased to the 7th week. In the control group, the animals peaked at the second to third weeks, and there was no significant change in the microvascular caliber and the third week in the seventh week. And according to the phase of the administration group and the control group, respectively, do the same period of comparison, it shows that the administration group of animal heart wall infarction area of the vascular hyperplasia than the control group were significantly different. Through the increase of blood vessel density and the change of caliber curve, we can conclude that nifedipine can obviously dilate the microvascular and improve the blood circulation in the myocardial infarction area, and further promote the pathological repair process in infarction area.