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目的：载脂蛋白Ｅ（ａｐｏＥ）基因多态性对缺血性脑血管疾病（ＩＣＶＤ）发生的影响。方法：临床筛选６７例缺血性脑血管病病人，利用聚合酶链反应（ＰＣＲ）技术进行ａｐｏＥ基因位点的扩增，然后用Ｈｈａ Ｉ酶切ＤＮＡ扩增产物，进行限制性片断长度多态性分析（ＲＦＬＰ），检测他们的ａｐｏＥ基因型，并与正常对照组比较，并同时检测血脂水平及血流变学指标。结果：ＩＣＶＤ组与健康对照组 ａｐｏＥ基因型分布无显著差异，不同类型 ＩＣＶＤ组 ａｐｏＥ基因型分布亦无显著差异．结论：ａｐｏＥ基因多态性不是缺血性脑血管病的危险因素。
Objective: To investigate the effect of apolipoprotein E (apoE) gene polymorphism on the occurrence of ischemic cerebrovascular disease (ICVD). Methods: Sixty-seven patients with ischemic cerebrovascular disease were screened by clinical screening. The apoE gene locus was amplified by polymerase chain reaction (PCR). The amplified product was digested with Hha I and subjected to restriction fragment length polymorphism Sex analysis (RFLP) was performed to detect their apoE genotypes, and compared with the normal control group. Meanwhile, blood lipid levels and hemorrheological indexes were also measured. Results: There was no significant difference in the distribution of apoE genotype between ICVD group and healthy control group. There was no significant difference in the distribution of apoE genotype between ICVD group and control group. Conclusion: ApoE gene polymorphism is not a risk factor for ischemic cerebrovascular disease.