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目的:探讨PEG-IFN-α-2a联合六味五灵片治疗HBeAg阳性慢性乙型肝炎(chronic hepatitis B,CHB)的临床疗效.方法:选择75例HBeAg阳性的CHB患者,随机分为观察组(38例)和对照组(37例),观察组给予PEG-IFN-α-2a 180μg,皮下注射1次/wk,同时服用六味五灵片2.0 g,3次/d.对照组给予PEG-IFN-α-2a 180μg皮下注射1次/wk,同时服用甘草酸二胺胶囊,疗程均为24 wk.结果:治疗24 wk后,观察组丙氨酸转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(glutamic-oxalacetic transaminase,AST)和总胆红素(total bilirubin,TBIL)值分别为24.9 U/L±16.6 U/L,21.2 U/L±16.5 U/L和18.1μmol/L±10.1μmol/L均显著低于对照组(44.7 U/L±19.7U/L、49.1 U/L±20.5 U/L和27.2μmol/L±17.4μmol/L,P<0.05),差异均具有显著性意义.治疗过程中,两组患者均未见明显不良反应.结论:PEG-IFN-α-2a联合六味五灵片可以有效地改善肝功能,同时不影响PEG-IFN-α-2a抑制乙型肝炎病毒复制的作用,值得临床推广应用.
Objective: To investigate the clinical efficacy of PEG-IFN-α-2a combined with Liuwei Wuling tablets in the treatment of HBeAg-positive chronic hepatitis B. Methods: Seventy-five CHB patients with HBeAg positive were randomly divided into observation group (N = 38) and control group (n = 37). The observation group was given PEG-IFN-α-2a 180μg and subcutaneous injection once / wk while taking Liuwei Wuling tablet 2.0g, - α-2a 180μg subcutaneously once a week, wk taking glycyrrhizic acid diamine capsules, the course of treatment was 24 wk.Results: After treatment for 24 weeks, the alanine aminotransferase (ALT), glutamic-pyruvic transaminase AST and total bilirubin (TBIL) were 24.9 U / L ± 16.6 U / L, 21.2 U / L ± 16.5 U / L and 18.1 μmol / L ± 10.1 μmol / L respectively (44.7 U / L ± 19.7U / L, 49.1 U / L ± 20.5 U / L and 27.2μmol / L ± 17.4μmol / L, P <0.05) .The difference was significant , No adverse reactions were observed in both groups.Conclusion: PEG-IFN-α-2a combined with Liuwei Wuling tablets can effectively improve liver function without affecting the inhibition of hepatitis B virus replication by PEG-IFN-α-2a Role, it is worth Application.